Nucleotide-binding oligomerization domain-containing protein-like receptor

{
  "id": "MLC-T-CHM-008145",
  "term": "Nucleotide-binding oligomerization domain-containing protein-like receptor",
  "field": "Chemistry",
  "definition": "A class of intracellular proteins that function as sensors for pathogen-associated molecular patterns and damage-associated molecular patterns, initiating innate immune responses. These receptors contain a central nucleotide-binding oligomerization domain (NOD or NACHT), a C-terminal leucine-rich repeat domain for ligand recognition, and a variable N-terminal effector domain. Mutations in genes encoding these proteins are associated with inflammatory conditions such as Crohn disease and Blau syndrome.",
  "synonyms": [
    "NOD-like receptor protein (NLRP)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Blau syndrome",
    "Crohn disease",
    "NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3",
    "asthma"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1222 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nucleotide-binding-oligomerization-domain-containing-protein-like-receptor/"
}