NOD-like receptor

{
  "id": "MLC-T-CHM-013338",
  "term": "NOD-like receptor",
  "field": "Chemistry",
  "definition": "A class of intracellular pattern recognition receptors that are part of the innate immune system. They detect specific molecular patterns associated with pathogens or cellular stress within the cytoplasm, triggering an inflammatory and antimicrobial response. These proteins characteristically contain a central nucleotide-binding oligomerization domain (NOD or NACHT), a C-terminal leucine-rich repeat (LRR) domain for sensing, and a variable N-terminal effector domain like a pyrin domain (PYD) for signaling.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3",
    "pattern recognition receptor"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1218 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nod-like-receptor/"
}