Nucleotide-binding oligomerization domain-containing protein 1, 2

{
  "id": "MLC-T-CHM-008144",
  "term": "Nucleotide-binding oligomerization domain-containing protein 1, 2",
  "field": "Chemistry",
  "definition": "A pair of intracellular pattern recognition receptors, NOD1 and NOD2, that detect specific peptidoglycan motifs from bacterial cell walls. NOD1 recognizes a dipeptide found in most Gram-negative bacteria, while NOD2 recognizes muramyl dipeptide, present in both Gram-positive and Gram-negative bacteria. Upon detection, they initiate an inflammatory response by activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "nuclear factor kappa-light-chain-enhancer of activated B cells"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1222 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nucleotide-binding-oligomerization-domain-containing-protein-1-2/"
}