Intrinsic clearance

{
  "id": "MLC-T-CHM-006026",
  "term": "Intrinsic clearance",
  "field": "Chemistry",
  "definition": "The inherent capacity of an organ, usually the liver, to remove or metabolize a drug when blood flow and protein binding place no limit on delivery, reflecting the efficiency of its enzymes and transporters, roughly Vmax divided by Km at low drug concentration. It sets hepatic clearance for low-extraction drugs, whereas the clearance of high-extraction drugs approaches liver blood flow and changes little with intrinsic clearance.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1247 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/intrinsic-clearance/"
}