Isobole approach

{
  "id": "MLC-T-CHM-006171",
  "term": "Isobole approach",
  "field": "Chemistry",
  "definition": "A graphical method for judging how two agents act together in a mixture, by plotting the dose pairs that produce the same fixed effect, such as a 50 percent response. The dose of each agent alone gives the two axis intercepts, and the straight line joining them marks additivity. Points falling below that line, on a concave isobole, indicate synergism, while points above it, on a convex isobole, indicate antagonism.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2009, 81, 829. 'Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009)' on page 902 (https://doi.org/10.1351/PAC-REC-08-07-09)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/isobole-approach/"
}