Isobaric tag for relative and absolute quantitation

{
  "id": "MLC-T-CHM-006170",
  "term": "Isobaric tag for relative and absolute quantitation",
  "field": "Chemistry",
  "definition": "A chemical reagent used in quantitative proteomics to label peptides from different samples. These tags are isobaric, meaning they have the same total mass, but are designed to produce unique reporter ions of different masses upon fragmentation in a mass spectrometer. The relative intensities of these reporter ions, observed in the MS/MS spectrum, are used to determine the relative abundance of the peptide in each original sample.",
  "subject": "Analytical Chemistry",
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1556 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/isobaric-tag-for-relative-and-absolute-quantitation/"
}