Isotope coded affinity tag

{
  "id": "MLC-T-CHM-006229",
  "term": "Isotope coded affinity tag",
  "field": "Chemistry",
  "definition": "A chemical reagent used in quantitative proteomics to label cysteine-containing peptides from different biological samples with either a 'light' or 'heavy' isotopic tag. After labeling, the samples are combined, digested, and analyzed by mass spectrometry. The ratio of the light and heavy forms of a peptide provides its relative abundance between the samples.",
  "subject": "Analytical Chemistry",
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1556 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/isotope-coded-affinity-tag/"
}