Knock-in

{
  "id": "MLC-T-CHM-006371",
  "term": "Knock-in",
  "field": "Chemistry",
  "definition": "A genetic engineering technique where a specific DNA sequence is inserted into a particular locus in the genome of a cell or organism. This allows for the expression of an exogenous gene or the modification of an endogenous gene. The inserted sequence can be a reporter gene, a human gene, or a gene with specific mutations.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "exogenous"
  ],
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1249 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/knock-in/"
}