Knock-out

Term · Chemistry · MLC-T-CHM-006372

A genetic manipulation technique that inactivates or deletes a specific gene in an organism, resulting in the absence of its functional protein product. This is achieved through homologous recombination or CRISPR/Cas9 gene editing, creating a stable, heritable genetic alteration. The resulting organism, a knock-out organism, is used to study gene function and disease mechanisms.

Table 1. Record
Identifier	MLC-T-CHM-006372
Field	Chemistry
Subject	Chemistry and Human Health
References	PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1249 (https://doi.org/10.1351/pac200779071153)

Record as JSON

{
  "id": "MLC-T-CHM-006372",
  "term": "Knock-out",
  "field": "Chemistry",
  "definition": "A genetic manipulation technique that inactivates or deletes a specific gene in an organism, resulting in the absence of its functional protein product. This is achieved through homologous recombination or CRISPR/Cas9 gene editing, creating a stable, heritable genetic alteration. The resulting organism, a knock-out organism, is used to study gene function and disease mechanisms.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1249 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/knock-out/"
}

Record 6,762 of 13,676 in Chemistry terminology (MLC-0109). Request the full dataset.