Kupffer cell

{
  "id": "MLC-T-CHM-006392",
  "term": "Kupffer cell",
  "field": "Chemistry",
  "definition": "A specialized type of residential macrophage located within the sinusoids of the liver, forming part of the mononuclear phagocyte system. These cells are the first line of defense in the liver, responsible for clearing pathogens, cellular debris, endotoxins, and other foreign particulate matter from the portal blood supply. Kupffer cells also participate in iron metabolism and can initiate inflammatory responses to liver injury or infection.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "macrophage",
    "residential macrophage"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1199 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/kupffer-cell/"
}