Maximum tolerated dose

{
  "id": "MLC-T-CHM-007060",
  "term": "Maximum tolerated dose",
  "field": "Chemistry",
  "definition": "The highest dose of a drug or chemical that can be given to an animal or human without causing unacceptable or life-threatening toxicity. This dose is determined in preclinical and clinical studies to identify a safe and effective dosing range. It is a key parameter in chronic toxicity studies and cancer chemotherapy.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "chronic toxicity",
    "dose",
    "toxicity",
    "weight"
  ],
  "references": [
    "PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2068 (https://doi.org/10.1351/pac199365092003)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/maximum-tolerated-dose/"
}