Mechanism-based inhibition

{
  "id": "MLC-T-CHM-007114",
  "term": "Mechanism-based inhibition",
  "field": "Chemistry",
  "definition": "A type of enzyme inhibition where an enzyme converts a substrate analog into a reactive intermediate that then irreversibly inactivates the enzyme. This process, also known as suicide inhibition, involves the enzyme's own catalytic machinery to generate the inactivating species. It is a highly specific form of inhibition often exploited in drug design.",
  "synonyms": [
    "suicide inhibition"
  ],
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "catalysis",
    "inhibition"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1138 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mechanism-based-inhibition/"
}