Minimum structural change, principle of

{
  "id": "MLC-T-CHM-007401",
  "term": "Minimum structural change, principle of",
  "field": "Chemistry",
  "definition": "The principle that a reaction is expected to occur with the fewest bond changes, meaning the fewest bonds made or broken and the least redistribution of electrons, so that a substitution replaces one group without altering the rest of the skeleton. Reactions that violate it by changing connectivity, such as skeletal rearrangements, are the ones classed as molecular rearrangements.",
  "subject": "Organic and Biomolecular Chemistry",
  "references": [
    "PAC, 2022, 94, 353. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)' on page 465 (https://doi.org/10.1515/pac-2018-1010)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/minimum-structural-change-principle-of/"
}