Murcko assembly

{
  "id": "MLC-T-CHM-007699",
  "term": "Murcko assembly",
  "field": "Chemistry",
  "definition": "A structural representation of a molecule that consists of its ring systems and the linkers connecting them, effectively removing all side chains. This core structure, also known as a Murcko framework or scaffold, is used to classify and analyze the diversity of chemical compounds. It provides a simplified view of molecular architecture for drug design.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "scaffold"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1742 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/murcko-assembly/"
}