Murine local lymph node assay

{
  "id": "MLC-T-CHM-007701",
  "term": "Murine local lymph node assay",
  "field": "Chemistry",
  "definition": "An in vivo test method used to identify potential skin sensitizers by measuring the proliferative response of lymphocytes in the draining lymph nodes of mice following topical application of a test substance. An increase in lymphoproliferation indicates a sensitizing potential. This assay is a recognized alternative to traditional guinea pig tests for skin sensitization.",
  "synonyms": [
    "local lymph node assay (LLNA)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "draining lymph node",
    "lymphoproliferation"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1216 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/murine-local-lymph-node-assay/"
}