Guinea pig maximization test

{
  "id": "MLC-T-CHM-005059",
  "term": "Guinea pig maximization test",
  "field": "Chemistry",
  "definition": "A standard animal test used to assess the potential of a substance to cause skin sensitization, an allergic reaction. Guinea pigs are exposed to the test substance, often with an adjuvant, to induce an immune response. The subsequent challenge exposure determines if a delayed-type hypersensitivity reaction occurs, indicating sensitization.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Freund’s adjuvant",
    "skin sensitization test",
    "allergic",
    "booster",
    "challenge",
    "contact dermatitis"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1172 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/guinea-pig-maximization-test/"
}