Split adjuvant technique

{
  "id": "MLC-T-CHM-011236",
  "term": "Split adjuvant technique",
  "field": "Chemistry",
  "definition": "A guinea pig assay for the skin-sensitizing potential of a chemical, in which the test substance is applied repeatedly to the skin while complete Freund's adjuvant is injected intradermally at a separate site, so the adjuvant boosts the immune response without being mixed with the chemical. After a rest period the animals are challenged on the skin, and reactions such as redness and swelling are scored against control animals.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Freund’s adjuvant",
    "allergic",
    "contact dermatitis"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1247 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/split-adjuvant-technique/"
}