Mouse ear-swelling test

{
  "id": "MLC-T-CHM-007603",
  "term": "Mouse ear-swelling test",
  "field": "Chemistry",
  "definition": "A bioassay for the skin-sensitizing potential of a chemical. Mice are first sensitized, then challenged by painting the substance on one ear, and the swelling that follows is measured as the inflammatory response, usually as the increase in ear thickness compared with control animals. It serves in immunotoxicology as a quicker screen than the guinea pig maximization test.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "challenge"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1214 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mouse-ear-swelling-test/"
}