Neurofibrillary tangle

{
  "id": "MLC-T-CHM-007872",
  "term": "Neurofibrillary tangle",
  "field": "Chemistry",
  "definition": "An intracellular aggregate of hyperphosphorylated tau protein that accumulates inside neurons in certain neurodegenerative disorders. These tangles are composed of paired helical filaments and straight filaments, which disrupt the neuron's internal transport system and contribute to cell death. The density of neurofibrillary tangles in the cerebral cortex is a primary pathological hallmark used in the diagnosis of Alzheimer disease.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Alzheimer disease",
    "paired helical filament",
    "tau protein"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 888 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/neurofibrillary-tangle/"
}