Paired helical filament

{
  "id": "MLC-T-CHM-008422",
  "term": "Paired helical filament",
  "field": "Chemistry",
  "definition": "An abnormal fibrillar structure found in the brains of individuals with Alzheimer's disease and other tauopathies. These filaments are composed primarily of hyperphosphorylated tau protein, which aggregates and forms neurofibrillary tangles. The accumulation of these structures is a hallmark pathological feature of these neurodegenerative conditions.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "neurofibrillary tangle",
    "tau protein"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 894 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/paired-helical-filament/"
}