Nuclear factor of activated T cells

{
  "id": "MLC-T-CHM-008098",
  "term": "Nuclear factor of activated T cells",
  "field": "Chemistry",
  "definition": "A family of transcription factors that regulate the expression of cytokine genes and other genes involved in the immune response, particularly in T cells. Activation of these factors is dependent on calcium signaling, which triggers their dephosphorylation by the phosphatase calcineurin. This dephosphorylation exposes a nuclear localization signal, permitting the factor to translocate to the nucleus and bind to DNA.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1222 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nuclear-factor-of-activated-t-cells/"
}