TDP-43 transcription factor

{
  "id": "MLC-T-CHM-011838",
  "term": "TDP-43 transcription factor",
  "field": "Chemistry",
  "definition": "A nuclear protein that binds to DNA and RNA, involved in gene transcription, messenger RNA splicing, and microRNA processing. It is normally found in the nucleus but can mislocalize to the cytoplasm in certain neurodegenerative diseases. Aggregates of this protein are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "amyotrophic lateral sclerosis",
    "frontotemporal dementia",
    "misfolded protein"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 910 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/tdp-43-transcription-factor/"
}