Calcineurin inhibitor

{
  "id": "MLC-T-CHM-001570",
  "term": "Calcineurin inhibitor",
  "field": "Chemistry",
  "definition": "A class of immunosuppressive drugs that block the activity of calcineurin, a phosphatase enzyme involved in T lymphocyte activation. By inhibiting calcineurin, these drugs prevent the dephosphorylation of NFAT (nuclear factor of activated T cells), thereby suppressing the transcription of cytokine genes like interleukin-2. Cyclosporine and tacrolimus are prominent examples used in organ transplantation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "immunomodulation",
    "interleukin"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1140 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/calcineurin-inhibitor/"
}