Signal transducer and activator of transcription

{
  "id": "MLC-T-CHM-010854",
  "term": "Signal transducer and activator of transcription",
  "field": "Chemistry",
  "definition": "A class of intracellular proteins that mediate cellular responses to cytokines and growth factors. Upon activation by Janus kinases (JAKs) at the cell surface receptor, these proteins dimerize, translocate to the nucleus, and bind to specific DNA sequences to regulate gene expression. The JAK/STAT signaling pathway, which involves these proteins, governs processes such as cell growth, differentiation, and immune response.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "JAK/STAT signaling pathway",
    "cytokine"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1244 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/signal-transducer-and-activator-of-transcription/"
}