Orphan receptor

{
  "id": "MLC-T-CHM-008332",
  "term": "Orphan receptor",
  "field": "Chemistry",
  "definition": "A receptor for which the endogenous ligand has not yet been identified. These receptors are discovered through genomic sequencing or homology searches, and their physiological function remains unknown until a specific binding molecule is found. Many orphan receptors belong to the G protein-coupled receptor family and are targets for drug discovery efforts.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1744 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/orphan-receptor/"
}