pH-partition hypothesis

{
  "id": "MLC-T-CHM-008942",
  "term": "pH-partition hypothesis",
  "field": "Chemistry",
  "definition": "A theory explaining the absorption of drugs across biological membranes based on their pKa and the pH of the environment. It posits that only the un-ionized form of a drug, which is more lipid-soluble, can readily cross lipid membranes. Therefore, the extent of absorption is influenced by the degree of ionization, which is determined by the drug's pKa and the local pH.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2009, 81, 829. 'Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009)' on page 926 (https://doi.org/10.1351/PAC-REC-08-07-09)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/ph-partition-hypothesis/"
}