Phase II reaction

{
  "id": "MLC-T-CHM-008740",
  "term": "Phase II reaction",
  "field": "Chemistry",
  "definition": "A metabolic process that involves the conjugation of a xenobiotic or its phase I metabolite with an endogenous, polar molecule, such as glucuronic acid, sulfate, or glutathione. These reactions typically increase the compound's water solubility and molecular weight, facilitating its excretion from the body. Enzymes like UDP-glucuronosyltransferases catalyze these conjugation reactions.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "conjugated system",
    "metabolite"
  ],
  "references": [
    "PAC, 2004, 76, 1033. 'Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)' on page 1064 (https://doi.org/10.1351/pac200476051033)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/phase-ii-reaction/"
}