Protamine

{
  "id": "MLC-T-CHM-009563",
  "term": "Protamine",
  "field": "Chemistry",
  "definition": "A small, arginine-rich protein that replaces histones late in spermatogenesis, condensing the DNA in the sperm head into a highly compact and stable structure. This compaction protects the paternal genome from damage during its journey to the egg. Protamine sulfate is used clinically as an antidote to heparin overdose.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "spermatozoon",
    "spermatogenesis"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 797 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/protamine/"
}