Steric-approach control

{
  "id": "MLC-T-CHM-011397",
  "term": "Steric-approach control",
  "field": "Chemistry",
  "definition": "A model used to predict the stereochemical outcome of a reaction, particularly additions to carbonyl compounds, based on the relative accessibility of the two faces of a planar or nearly planar reactant. The attacking reagent approaches the less hindered face of the molecule. This concept is often applied to reactions involving chiral substrates.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "product development control",
    "stereoselectivity",
    "steric hindrance",
    "transition state"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1168 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/steric-approach-control/"
}