Tetrodotoxin-insensitive

{
  "id": "MLC-T-CHM-011909",
  "term": "Tetrodotoxin-insensitive",
  "field": "Chemistry",
  "definition": "Describing voltage-gated sodium channels that are not blocked by the neurotoxin tetrodotoxin, indicating a structural difference in their pore region compared to tetrodotoxin-sensitive channels. These channels often exhibit distinct electrophysiological properties and are found in specific neuronal populations. For example, certain cardiac sodium channels are known to be tetrodotoxin-insensitive.",
  "synonyms": [
    "TTX-insensitive"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "ion channel",
    "tetrodotoxin"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 911 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/tetrodotoxin-insensitive/"
}