Tetrodotoxin

{
  "id": "MLC-T-CHM-011908",
  "term": "Tetrodotoxin",
  "field": "Chemistry",
  "definition": "A potent neurotoxin produced by certain marine organisms, such as pufferfish and blue-ringed octopuses, that selectively blocks voltage-gated sodium channels in nerve cell membranes. This blockade prevents the generation and propagation of action potentials, leading to paralysis and respiratory failure. It is a non-protein toxin with a molecular formula of C11H17N3O8.",
  "synonyms": [
    "4R,4aR,5R,6S,7S,8S,8aR,10S,12S)-2-azaniumylidene-4,6,8,12-tetrahydroxy-6-(hydroxymethyl)-2,3,4,4a,5,6,7,8-octahydro-1H-8a,10-methano-5,7-(epoxymethanooxy)quinazolin-10-olate"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "neurotoxin",
    "action potential",
    "ion channel"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 911 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/tetrodotoxin/"
}