Topomerization

{
  "id": "MLC-T-CHM-012117",
  "term": "Topomerization",
  "field": "Chemistry",
  "definition": "A degenerate isomerization in which identical ligands or atoms in a molecule exchange positions, so that the starting and final molecular entities, called topomers, are indistinguishable. Examples are ring inversion of cyclohexane, which swaps axial and equatorial hydrogens, and hindered rotation about a bond, which exchanges identical groups. The exchange is usually detected by dynamic NMR spectroscopy, where signals of the exchanging sites coalesce on warming.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "identity reaction",
    "isomerization",
    "ligands",
    "spectroscopy"
  ],
  "references": [
    "PAC, 1996, 68, 2193. 'Basic terminology of stereochemistry (IUPAC Recommendations 1996)' on page 2220 (https://doi.org/10.1351/pac199668122193)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/topomerization/"
}