Tumor suppressor gene

{
  "id": "MLC-T-CHM-012353",
  "term": "Tumor suppressor gene",
  "field": "Chemistry",
  "definition": "A gene that regulates cell growth and division, typically by inhibiting cell proliferation or promoting apoptosis, thereby preventing the development of cancer. Loss-of-function mutations in both alleles of these genes can lead to uncontrolled cell growth and tumor formation. Examples include TP53, BRCA1, and RB1.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1330 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/tumor-suppressor-gene/"
}