Universal calibration

{
  "id": "MLC-T-CHM-012442",
  "term": "Universal calibration",
  "field": "Chemistry",
  "definition": "A method used in size-exclusion chromatography (SEC) to determine the molar mass of a polymer sample independently of its chemical structure. It relies on the principle that the hydrodynamic volume of a polymer in solution, rather than its molar mass, dictates its elution behavior. This method typically involves plotting the product of intrinsic viscosity and molar mass against elution volume.",
  "subject": "Polymer",
  "see_also": [
    "intrinsic viscosity",
    "size-exclusion chromatography"
  ],
  "references": [
    "Purple Book, 1st ed., p. 69 (http://old.iupac.org/publications/books/author/metanomski.html)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/universal-calibration/"
}