Wheal and flare

{
  "id": "MLC-T-CHM-012690",
  "term": "Wheal and flare",
  "field": "Chemistry",
  "definition": "A characteristic biphasic skin reaction observed during immediate hypersensitivity responses, such as allergic reactions or intradermal histamine injection. The wheal is a central, raised, edematous area caused by local vasodilation and fluid leakage, while the flare is a surrounding area of redness (erythema) due to arteriolar dilation. This reaction is mediated by mast cell degranulation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allergic",
    "erythema",
    "wheal"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1260 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/wheal-and-flare/"
}