Anaplasia

{
  "id": "MLC-T-CHM-000569",
  "term": "Anaplasia",
  "field": "Chemistry",
  "definition": "A condition in which cells lose their specialized characteristics and revert to a more primitive, undifferentiated form. This cellular dedifferentiation is a hallmark of malignancy, where cells exhibit pleomorphism, increased nuclear-to-cytoplasmic ratio, and abnormal mitotic figures. Anaplastic cells often show uncontrolled proliferation and a reduced ability to perform their normal functions.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1167 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/anaplasia/"
}