Autoimmune lymphoproliferative syndrome

{
  "id": "MLC-T-CHM-000977",
  "term": "Autoimmune lymphoproliferative syndrome",
  "field": "Chemistry",
  "definition": "A rare genetic disorder characterized by the chronic, non-malignant proliferation of lymphocytes, leading to the enlargement of the spleen, liver, and lymph nodes. The condition results from a failure of apoptosis (programmed cell death) in lymphocytes, causing them to accumulate. Patients often develop autoimmune phenomena, such as cytopenias, and have an increased lifetime risk of developing lymphoma.",
  "synonyms": [
    "Canale-Smith syndrome"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autoimmune",
    "cytopenia",
    "hypergammaglobulinemia",
    "lymphadenopathy"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1130 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/autoimmune-lymphoproliferative-syndrome/"
}