Coil-to-globule transition

{
  "id": "MLC-T-CHM-002190",
  "term": "Coil-to-globule transition",
  "field": "Chemistry",
  "definition": "A conformational change in a single polymer chain where it collapses from an extended, random coil state into a compact, dense globule. This transition occurs when the solvent quality worsens or temperature changes, making intramolecular attractive forces dominant over polymer-solvent interactions. It is a reversible process, often observed in dilute polymer solutions.",
  "subject": "Polymer",
  "see_also": [
    "globule-to-coil transition"
  ],
  "references": [
    "PAC, 2012, 85, 463. 'Terminology for aggregation and self-assembly in polymer science (IUPAC Recommendations 2013)' on page 467 (https://doi.org/10.1351/PAC-REC-12-03-12)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/coil-to-globule-transition/"
}