Conditioning solvent

{
  "id": "MLC-T-CHM-002393",
  "term": "Conditioning solvent",
  "field": "Chemistry",
  "definition": "A solvent passed through a solid-phase extraction sorbent prior to sample loading. The purpose is to wet the sorbent material and create a chemical environment on the stationary phase that is compatible with the sample matrix and conducive to the desired retention mechanism. For reverse-phase sorbents, this typically involves first washing with a strong organic solvent like methanol, followed by an aqueous solution similar to the sample solvent.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "sorbent"
  ],
  "references": [
    "PAC, 2016, 88, 517. 'Glossary of terms used in extraction (IUPAC Recommendations 2016)' on page 541 (https://doi.org/10.1515/pac-2015-0903)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/conditioning-solvent/"
}