Developmental susceptibility gene

{
  "id": "MLC-T-CHM-003105",
  "term": "Developmental susceptibility gene",
  "field": "Chemistry",
  "definition": "A gene whose product is required for normal development, and for which certain alleles or variants increase the risk of adverse outcomes following exposure to a toxicant. The specific polymorphism in the gene does not cause a defect on its own but modifies the organism's response to an environmental challenge. An example is a gene variant that alters the metabolism of a xenobiotic, leading to a higher concentration of a teratogenic metabolite.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "gene product"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 743 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/developmental-susceptibility-gene/"
}