Efflux pump

{
  "id": "MLC-T-CHM-003609",
  "term": "Efflux pump",
  "field": "Chemistry",
  "definition": "A transmembrane protein that actively transports substrates, such as drugs, toxins, and metabolites, out of a cell. This process requires energy, often derived from the hydrolysis of adenosine triphosphate (ATP), to move substances against their concentration gradient. The P-glycoprotein is a well-studied example of an efflux pump responsible for multidrug resistance in cancer cells by expelling chemotherapeutic agents.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "ATP binding cassette protein",
    "P-glycoprotein"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1734 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/efflux-pump/"
}