P-glycoprotein

{
  "id": "MLC-T-CHM-008703",
  "term": "P-glycoprotein",
  "field": "Chemistry",
  "definition": "A membrane-bound transport protein that actively pumps a wide variety of substances out of cells, a process driven by the hydrolysis of adenosine triphosphate (ATP). This efflux pump is a member of the ATP-binding cassette (ABC) transporter superfamily and is found in the cell membranes of many tissues, including the intestine, liver, kidneys, and brain capillaries. Overexpression of P-glycoprotein in cancer cells is a primary mechanism of multidrug resistance, as it expels chemotherapeutic agents from the cell.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "ATP binding cassette protein",
    "efflux pump",
    "multidrug resistance"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1745 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/p-glycoprotein/"
}