Hyperimmunoglobulin M syndrome

{
  "id": "MLC-T-CHM-005515",
  "term": "Hyperimmunoglobulin M syndrome",
  "field": "Chemistry",
  "definition": "A rare primary immunodeficiency disorder characterized by normal or elevated levels of immunoglobulin M (IgM) but very low or absent levels of other immunoglobulin classes, such as IgG, IgA, and IgE. This condition results from defects in B cell class switching, often due to mutations in genes like CD40 ligand. Patients are highly susceptible to recurrent bacterial infections.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autoimmune",
    "CD40 ligand",
    "T lymphocyte",
    "arthritis",
    "cytopenia",
    "immunoglobulin A",
    "immunoglobulin G"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1180 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hyperimmunoglobulin-m-syndrome/"
}