Common variable immunodeficiency

{
  "id": "MLC-T-CHM-002281",
  "term": "Common variable immunodeficiency",
  "field": "Chemistry",
  "definition": "A primary immunodeficiency disorder characterized by low levels of most or all immunoglobulin isotypes, particularly immunoglobulin G (IgG), IgA, and IgM. This condition results in a failure to produce a proper antibody response following antigen exposure, leading to recurrent bacterial infections, especially of the respiratory and gastrointestinal tracts. Diagnosis is confirmed by measuring serum immunoglobulin levels and assessing the antibody response to vaccines.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "immunoglobulin G",
    "major histocompatibility complex",
    "plasma cell",
    "gammaglobulin"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1146 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/common-variable-immunodeficiency/"
}