CD40 ligand

{
  "id": "MLC-T-CHM-012955",
  "term": "CD40 ligand",
  "field": "Chemistry",
  "definition": "A transmembrane protein, also known as CD154, that is primarily expressed on the surface of activated T lymphocytes. It functions as a co-stimulatory molecule by binding to its receptor, CD40, which is present on antigen-presenting cells like B lymphocytes, macrophages, and dendritic cells. This interaction stimulates B cell proliferation, differentiation, and antibody class switching; genetic defects in the CD40 ligand gene result in hyperimmunoglobulin M syndrome.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "T lymphocyte",
    "hyperimmunoglobulin M syndrome"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1139 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/cd40-ligand/"
}