Inducible co-stimulatory protein

{
  "id": "MLC-T-CHM-005796",
  "term": "Inducible co-stimulatory protein",
  "field": "Chemistry",
  "definition": "A transmembrane protein of the CD28/CTLA-4 family that is expressed on the surface of activated T lymphocytes. It provides positive co-stimulatory signals to T cells following engagement with its ligand, promoting T cell proliferation, survival, and cytokine secretion. The specific ligand for this protein is ICOS-L (B7-H2), which is found on antigen-presenting cells, including B cells and macrophages.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "T lymphocyte",
    "lymphocyte activation",
    "immune system",
    "macrophage"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1193 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/inducible-co-stimulatory-protein/"
}