Co-stimulation

{
  "id": "MLC-T-CHM-002618",
  "term": "Co-stimulation",
  "field": "Chemistry",
  "definition": "A second activating signal that a lymphocyte needs alongside the signal it receives through its antigen-specific receptor before it becomes fully activated. For a T cell this signal normally comes from contact with molecules on the antigen-presenting cell. The best-known pair is B7 (CD80 or CD86) on the presenting cell binding CD28 on the T cell; antigen recognition without it leaves the T cell anergic.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "B7 molecule",
    "CD40 ligand",
    "T lymphocyte",
    "antigen presentation",
    "antigen-presenting cell",
    "helper T lymphocyte",
    "lymphocyte"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1150 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/co-stimulation/"
}