Ion suppression

{
  "id": "MLC-T-CHM-006096",
  "term": "Ion suppression",
  "field": "Chemistry",
  "definition": "A phenomenon in mass spectrometry where the signal intensity of an analyte ion is reduced due to the presence of co-eluting matrix components. These matrix components compete with the analyte for ionization, leading to a decrease in the number of analyte ions detected. This effect is particularly prevalent in electrospray ionization and can impact quantification accuracy.",
  "synonyms": [
    "ionization suppression"
  ],
  "subject": "Analytical Chemistry",
  "see_also": [
    "atmospheric pressure chemical ionization",
    "ion enhancement"
  ],
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1555 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/ion-suppression/"
}