Ionized calcium-binding adapter molecule 1

{
  "id": "MLC-T-CHM-006127",
  "term": "Ionized calcium-binding adapter molecule 1",
  "field": "Chemistry",
  "definition": "A protein expressed specifically in microglial cells and macrophages that is involved in the inflammatory response within the central nervous system. It functions as a calcium-binding protein and is upregulated during the activation of microglia, a key process in neuroinflammation following brain injury or disease. The detection of this molecule is widely used as a specific immunohistochemical marker to identify and quantify activated microglia in tissue samples.",
  "synonyms": [
    "allograft inflammatory factor 1 (AIF-1)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "brain",
    "inflammation",
    "microglial cell"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 876 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/ionized-calcium-binding-adapter-molecule-1/"
}