Lupus anticoagulant

{
  "id": "MLC-T-CHM-006815",
  "term": "Lupus anticoagulant",
  "field": "Chemistry",
  "definition": "An autoantibody that interferes with in vitro phospholipid-dependent coagulation tests, leading to prolonged clotting times, despite paradoxically increasing the risk of thrombosis in vivo. These antibodies are directed against phospholipid-binding proteins, such as beta-2-glycoprotein I or prothrombin. The presence of lupus anticoagulant is a diagnostic criterion for antiphospholipid syndrome.",
  "synonyms": [
    "antibody",
    "lupus",
    "lupus antibody"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autoantibody",
    "systemic lupus erythematosus"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1124 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lupus-anticoagulant/"
}